Amiodaron hidroklorid

Management of resistant, life-threatening ventricular arrhythmias or paroxysmal supraventricular tachycardia (PSVT) unresponsive to less toxic agents (class III antiarrhythmic agent; prolongs action potential and refractory period in myocardial tissue).
Oral dose: Infants and children:
<1 yr: 600–800 mg/1.73 m2/24 hr in 2 divided doses.
>1 yr: 10–20 mg/kg/24 hr in 2 divided doses for 10 days, then 5–10 mg/kg/24 hr.
Adults: 800 mg/24 hr in 2 divided doses.

Cut all doses in half (i.e.,1 dose/day) after 1–4 wk of treatment or when arrhythmias are controlled.
IV dose: Infants and children: Loading dose of 5 mg/kg over 1 hr, then continuous infusion of 5–15 μg/kg/min. pulmonary toxicity (potentially fatal) including pulmonary fibrosis,
Adults: 150 mg over 10 min, then 0.5 mg/min.

Beyaz Hastane